Diagnostic Performance of 60 MHz High-Definition Intravascular Ultrasound versus Fourier Domain Optical Coherence Tomography for Identifying Plaque Rupture, Plaque Erosion, and Thrombosis in a Rabbit Model

Background: Most acute coronary syndromes occur due to thrombosis caused by plaque rupture (PR) and erosion (PE). Precise in vivo differentiation between PR PE is challenging for intravascular imaging. This study the first determine diagnostic performance of novel 60 MHz high-definition ultrasound (HD-IVUS) differentiating atherosclerotic morphology influenced local hemodynamic flow rabbits. evaluated HD-IVUS identifying Methods: We established rabbit models atherosclerosis with left common carotid artery (LCCA) stenosis 30 FeCl3-induced LCCA thrombosis. Intravascular imaging was assessed fourier-domain optical coherence tomography (FD-OCT). The present investigated accuracy PE, as well thrombosis, using OCT-diagnosis a standard reference. Results: cavity minor intimal irregularities showed high sensitivity specificity; 92.0 90.0% OCT-defined PR, 80.0 70.0% respectively. In thrombus model, (88.0%) specificity (80.0%) Conclusions: can accurately identify Further studies should confirm clinical value this technique diagnosis.